Drug interactions
Macimorelin + Nilotinib
Severity: Major
Macimorelin and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a modest QT increase and nilotinib prolongs QT substantially, so combined use is additive. This raises the risk of torsades de pointes during testing.
What this interaction means in plain words
Macimorelin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid macimorelin testing while nilotinib is on board, or use an alternative growth hormone stimulation test.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Nilotinib?
MediHelp rates the interaction as major. Macimorelin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a modest QT increase and nilotinib prolongs QT substantially, so combined use is additive. This raises the risk of torsades de pointes during testing.
How serious is the interaction between Macimorelin and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while nilotinib is on board, or use an alternative growth hormone stimulation test.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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