Drug interactions
Macimorelin + Nortriptyline
Severity: Moderate
Macimorelin and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in QTc, and nortriptyline can also prolong the QT interval. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Macimorelin and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Hold nortriptyline for an adequate washout before the macimorelin test where clinically feasible. Otherwise correct electrolytes and consider ECG monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Nortriptyline?
MediHelp rates the interaction as moderate. Macimorelin and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in QTc, and nortriptyline can also prolong the QT interval. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Macimorelin and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold nortriptyline for an adequate washout before the macimorelin test where clinically feasible. Otherwise correct electrolytes and consider ECG monitoring.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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