Drug interactions
Macimorelin + Oxcarbazepine
Severity: Moderate
Macimorelin and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers can lower macimorelin levels and produce falsely abnormal growth hormone stimulation test results. Oxcarbazepine is a weaker inducer but may have a similar effect. The diagnostic result may be unreliable.
What this interaction means in plain words
Macimorelin and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction lowers macimorelin exposure and blunts the growth hormone response.
What to do
If clinically feasible, hold oxcarbazepine with adequate washout before testing, or interpret results cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Macimorelin and Oxcarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Oxcarbazepine?
MediHelp rates the interaction as moderate. Macimorelin and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers can lower macimorelin levels and produce falsely abnormal growth hormone stimulation test results. Oxcarbazepine is a weaker inducer but may have a similar effect. The diagnostic result may be unreliable.
How serious is the interaction between Macimorelin and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clinically feasible, hold oxcarbazepine with adequate washout before testing, or interpret results cautiously.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
