Drug interactions
Macimorelin + Pazopanib
Severity: Major
Macimorelin and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combined use could increase the risk of torsades de pointes. Macimorelin is used for a single diagnostic test, so timing can be managed.
What this interaction means in plain words
Macimorelin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination; if the test is needed, use an alternative diagnostic approach or allow adequate washout of pazopanib before macimorelin where clinically feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Pazopanib?
MediHelp rates the interaction as major. Macimorelin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combined use could increase the risk of torsades de pointes. Macimorelin is used for a single diagnostic test, so timing can be managed.
How serious is the interaction between Macimorelin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if the test is needed, use an alternative diagnostic approach or allow adequate washout of pazopanib before macimorelin where clinically feasible.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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