Drug interactions
Macimorelin + Pimavanserin
Severity: Major
Macimorelin and Pimavanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so used together they may increase the risk of torsades de pointes. Macimorelin is a single-dose diagnostic test for growth hormone deficiency.
What this interaction means in plain words
Macimorelin and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid macimorelin testing while pimavanserin is on board; schedule the test after a sufficient washout or use an alternative diagnostic agent. If it must be done, obtain an ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Macimorelin and Pimavanserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Pimavanserin?
MediHelp rates the interaction as major. Macimorelin and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so used together they may increase the risk of torsades de pointes. Macimorelin is a single-dose diagnostic test for growth hormone deficiency.
How serious is the interaction between Macimorelin and Pimavanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while pimavanserin is on board; schedule the test after a sufficient washout or use an alternative diagnostic agent. If it must be done, obtain an ECG.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
