Drug interactions
Macimorelin + Quinine
Severity: Major
Macimorelin and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT increase and quinine prolongs QT, so combined use raises the risk of torsades de pointes. Macimorelin is a single-dose diagnostic, so exposure is brief.
What this interaction means in plain words
Macimorelin and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Delay macimorelin testing until quinine has been cleared, or use another diagnostic approach. Do not test during quinine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Quinine?
MediHelp rates the interaction as major. Macimorelin and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT increase and quinine prolongs QT, so combined use raises the risk of torsades de pointes. Macimorelin is a single-dose diagnostic, so exposure is brief.
How serious is the interaction between Macimorelin and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay macimorelin testing until quinine has been cleared, or use another diagnostic approach. Do not test during quinine therapy.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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