Drug interactions
Macimorelin + Sorafenib
Severity: Moderate
Macimorelin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QT interval and sorafenib can also prolong it. Together they may increase the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Defer macimorelin testing until sorafenib is stopped and cleared where feasible, or use another growth hormone stimulation test. If testing proceeds, monitor the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Sorafenib?
MediHelp rates the interaction as moderate. Macimorelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in the QT interval and sorafenib can also prolong it. Together they may increase the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer macimorelin testing until sorafenib is stopped and cleared where feasible, or use another growth hormone stimulation test. If testing proceeds, monitor the ECG.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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