Drug interactions
Macimorelin + Sunitinib
Severity: Moderate
Macimorelin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin produces a modest QT prolongation and sunitinib can also prolong the QT interval. Giving them together could increase the risk of torsades de pointes.
What this interaction means in plain words
Macimorelin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid performing the macimorelin test while the patient is taking sunitinib unless essential. If needed, use a diagnostic alternative or allow adequate washout and check the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Sunitinib?
MediHelp rates the interaction as moderate. Macimorelin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin produces a modest QT prolongation and sunitinib can also prolong the QT interval. Giving them together could increase the risk of torsades de pointes.
How serious is the interaction between Macimorelin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid performing the macimorelin test while the patient is taking sunitinib unless essential. If needed, use a diagnostic alternative or allow adequate washout and check the ECG.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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