Drug interactions
Magnesium + Sarecycline
Severity: Moderate
Magnesium and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing products bind tetracycline-class antibiotics in the gut and reduce their absorption. This may lower sarecycline efficacy.
What this interaction means in plain words
Magnesium and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of sarecycline by divalent magnesium cations in the gastrointestinal tract.
What to do
Separate sarecycline from magnesium-containing antacids or supplements by at least 2 to 3 hours, taking sarecycline first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Magnesium with Sarecycline?
MediHelp rates the interaction as moderate. Magnesium and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing products bind tetracycline-class antibiotics in the gut and reduce their absorption. This may lower sarecycline efficacy.
How serious is the interaction between Magnesium and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline from magnesium-containing antacids or supplements by at least 2 to 3 hours, taking sarecycline first.
What other medicines interact with Sarecycline?
MediHelp also lists interactions of Sarecycline with, for example, Acitretin, Isotretinoin, Tretinoin. The full list is on the Sarecycline page.
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