Drug interactions
Magnesium hydroxide + Pazopanib
Severity: Moderate
Magnesium hydroxide and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on an acidic gastric environment, and magnesium hydroxide raises gastric pH. Lower pazopanib exposure may reduce antitumor efficacy. The effect of short-acting antacids is less than that of proton pump inhibitors if doses are separated.
What this interaction means in plain words
Magnesium hydroxide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of pazopanib.
What to do
If an antacid is needed, take pazopanib at least 2 hours before or 1 hour after it. Prefer antacids over PPIs or H2 blockers and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Magnesium hydroxide with Pazopanib?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on an acidic gastric environment, and magnesium hydroxide raises gastric pH. Lower pazopanib exposure may reduce antitumor efficacy. The effect of short-acting antacids is less than that of proton pump inhibitors if doses are separated.
How serious is the interaction between Magnesium hydroxide and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, take pazopanib at least 2 hours before or 1 hour after it. Prefer antacids over PPIs or H2 blockers and monitor treatment response.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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