Drug interactions
Magnesium hydroxide + Penicillamine
Severity: Moderate
Magnesium hydroxide and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing magnesium or aluminum reduce the absorption of oral penicillamine, which may weaken its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis.
What this interaction means in plain words
Magnesium hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Penicillamine belongs to Musculoskeletal.
Why it happens
Binding of penicillamine by metal cations and altered gastric conditions reduce its absorption.
What to do
Separate penicillamine from magnesium hydroxide by at least 2 hours and monitor therapeutic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Magnesium hydroxide with Penicillamine?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing magnesium or aluminum reduce the absorption of oral penicillamine, which may weaken its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis.
How serious is the interaction between Magnesium hydroxide and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate penicillamine from magnesium hydroxide by at least 2 hours and monitor therapeutic response.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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