Drug interactions
Magnesium hydroxide + Sotorasib
Severity: Moderate
Magnesium hydroxide and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib absorption is reduced by acid-suppressing drugs because its solubility depends on gastric pH. Locally acting antacids may lower exposure and potentially reduce efficacy.
What this interaction means in plain words
Magnesium hydroxide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Increased gastric pH from the antacid reduces dissolution and absorption of sotorasib.
What to do
Give sotorasib 4 hours before or 10 hours after magnesium hydroxide. Avoid proton pump inhibitors and H2 blockers where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Magnesium hydroxide with Sotorasib?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib absorption is reduced by acid-suppressing drugs because its solubility depends on gastric pH. Locally acting antacids may lower exposure and potentially reduce efficacy.
How serious is the interaction between Magnesium hydroxide and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give sotorasib 4 hours before or 10 hours after magnesium hydroxide. Avoid proton pump inhibitors and H2 blockers where possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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