Drug interactions
Magnesium hydroxide + Tobramycin
Severity: Minor
Magnesium hydroxide and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin can cause renal magnesium wasting and hypomagnesemia through tubular effects. The impact on magnesium hydroxide use is minor, but low magnesium may worsen aminoglycoside toxicity risks.
What this interaction means in plain words
Magnesium hydroxide and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium hydroxide belongs to Gastrointestinal Tract; Tobramycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside-induced tubular dysfunction increases urinary magnesium loss.
What to do
Monitor serum magnesium, potassium and renal function during tobramycin therapy and correct deficits promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Magnesium hydroxide with Tobramycin?
MediHelp rates the interaction as minor. Magnesium hydroxide and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tobramycin can cause renal magnesium wasting and hypomagnesemia through tubular effects. The impact on magnesium hydroxide use is minor, but low magnesium may worsen aminoglycoside toxicity risks.
How serious is the interaction between Magnesium hydroxide and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and renal function during tobramycin therapy and correct deficits promptly.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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