Drug interactions
Magnesium oxide + Nilotinib
Severity: Moderate
Magnesium oxide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids such as magnesium oxide may reduce the absorption of nilotinib capsules by altering gastric pH. This could lower nilotinib exposure and efficacy.
What this interaction means in plain words
Magnesium oxide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium oxide belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Antacid-related rise in gastric pH reduces pH-dependent dissolution and absorption of nilotinib.
What to do
Separate dosing by taking the antacid at least 2 hours before or 2 hours after nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Nilotinib?
MediHelp rates the interaction as moderate. Magnesium oxide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids such as magnesium oxide may reduce the absorption of nilotinib capsules by altering gastric pH. This could lower nilotinib exposure and efficacy.
How serious is the interaction between Magnesium oxide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by taking the antacid at least 2 hours before or 2 hours after nilotinib.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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