Drug interactions
Magnesium oxide + Ofloxacin
Severity: Moderate
Magnesium oxide and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide, an antacid and supplement, binds oral ofloxacin in the gut and reduces its absorption. This may lower antibiotic effectiveness.
What this interaction means in plain words
Magnesium oxide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium oxide belongs to Gastrointestinal Tract; Ofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of ofloxacin by magnesium cations in the gastrointestinal tract.
What to do
Give oral ofloxacin at least 2 hours before or 4 to 6 hours after magnesium oxide. Use an alternative if separation is not feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Ofloxacin?
MediHelp rates the interaction as moderate. Magnesium oxide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium oxide, an antacid and supplement, binds oral ofloxacin in the gut and reduces its absorption. This may lower antibiotic effectiveness.
How serious is the interaction between Magnesium oxide and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ofloxacin at least 2 hours before or 4 to 6 hours after magnesium oxide. Use an alternative if separation is not feasible.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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