Drug interactions
Magnesium oxide + Penicillamine
Severity: Moderate
Magnesium oxide and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide, an antacid and supplement, can bind penicillamine in the gut and reduce how much is absorbed. Therapeutic effect of penicillamine may be diminished.
What this interaction means in plain words
Magnesium oxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium oxide belongs to Gastrointestinal Tract; Penicillamine belongs to Musculoskeletal.
Why it happens
Chelation by magnesium and increased gastric pH reduce penicillamine absorption.
What to do
Separate doses by at least 2 hours and monitor clinical response to penicillamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Penicillamine?
MediHelp rates the interaction as moderate. Magnesium oxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium oxide, an antacid and supplement, can bind penicillamine in the gut and reduce how much is absorbed. Therapeutic effect of penicillamine may be diminished.
How serious is the interaction between Magnesium oxide and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor clinical response to penicillamine.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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