Drug interactions
Magnesium oxide + Spironolactone
Severity: Minor
Magnesium oxide and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone reduces urinary magnesium loss, so it can raise magnesium levels when magnesium is supplemented. Clinically significant hypermagnesemia is uncommon unless renal function is impaired.
What this interaction means in plain words
Magnesium oxide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium oxide belongs to Gastrointestinal Tract; Spironolactone belongs to Cardiovascular.
Why it happens
Aldosterone antagonism reduces renal magnesium wasting, adding to supplemental magnesium exposure.
What to do
Monitor serum magnesium in patients with renal impairment receiving magnesium supplements.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Spironolactone?
MediHelp rates the interaction as minor. Magnesium oxide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone reduces urinary magnesium loss, so it can raise magnesium levels when magnesium is supplemented. Clinically significant hypermagnesemia is uncommon unless renal function is impaired.
How serious is the interaction between Magnesium oxide and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in patients with renal impairment receiving magnesium supplements.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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