Drug interactions
Maitake + Metolazone
Severity: Minor
Maitake and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom may lower blood glucose and blood pressure, which could add to the blood pressure effect of metolazone. The claimed risk of hypokalemia is theoretical and poorly supported by clinical data.
What this interaction means in plain words
Maitake and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive blood pressure lowering; the mechanism is not firmly established.
What to do
Monitor blood pressure and serum potassium if maitake supplements are used regularly. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Maitake with Metolazone?
MediHelp rates the interaction as minor. Maitake and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom may lower blood glucose and blood pressure, which could add to the blood pressure effect of metolazone. The claimed risk of hypokalemia is theoretical and poorly supported by clinical data.
How serious is the interaction between Maitake and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium if maitake supplements are used regularly. No dose change is usually required.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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