Drug interactions
Mannitol + Voclosporin
Severity: Moderate
Mannitol and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, causes dose-related nephrotoxicity. Mannitol can cause osmotic kidney injury and acute kidney injury, especially with volume depletion, so using them together may increase the risk of renal impairment.
What this interaction means in plain words
Mannitol and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mannitol belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity: calcineurin inhibitor afferent vasoconstriction combined with mannitol osmotic tubular injury.
What to do
Monitor eGFR, serum creatinine and fluid status closely during and after mannitol. Reduce or interrupt voclosporin per labeling if renal function falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mannitol and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mannitol
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Mannitol with Voclosporin?
MediHelp rates the interaction as moderate. Mannitol and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, causes dose-related nephrotoxicity. Mannitol can cause osmotic kidney injury and acute kidney injury, especially with volume depletion, so using them together may increase the risk of renal impairment.
How serious is the interaction between Mannitol and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, serum creatinine and fluid status closely during and after mannitol. Reduce or interrupt voclosporin per labeling if renal function falls.
What other medicines interact with Mannitol?
MediHelp also lists interactions of Mannitol with, for example, Dexamethasone-tobramycin, Tobramycin, Dichlorphenamide. The full list is on the Mannitol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
