Drug reference
mannitol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Diuretics)
Mechanism of action
Osmotic diuretic When administered IV, exerts its osmotic effect as a solute of relatively small molecular size being largely confined to the extracellular space, Mannitol hinders tubular reabsorption of water and enhances excretion of sodium and chloride by elevating the osmolarity of the glomerular filtrate.
Common side effects
- Headache
- Cardiac arrest
- Hypotension
- Azotemia
- Seizures
- Venous thrombosis or phlebitis
Contraindications
- Hypersensitivity Anuria Severe hypovolemia Pre-existing severe pulmonary vascular congestion or pulmonary edema Active intracranial bleeding, except during craniotomy
Related conditions
Frequently asked questions
What drug class is mannitol?
mannitol belongs to: Cardiovascular.
How does mannitol work?
Osmotic diuretic When administered IV, exerts its osmotic effect as a solute of relatively small molecular size being largely confined to the extracellular space, Mannitol hinders tubular reabsorption of water and enhances excretion of sodium and chloride by elevating the osmolarity of the glomerular filtrate.
What are the common side effects of mannitol?
Headache, Cardiac arrest, Hypotension, Azotemia, Seizures, Venous thrombosis or phlebitis
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