Drug interactions
Maprotiline + Memantine-donepezil
Severity: Moderate
Maprotiline and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has anticholinergic properties that oppose donepezil and can worsen cognition. Both drugs can also prolong the QT interval, and maprotiline lowers the seizure threshold.
What this interaction means in plain words
Maprotiline and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of cholinergic transmission plus additive QT prolongation.
What to do
Prefer an antidepressant with minimal anticholinergic effects. If maprotiline is used, monitor ECG, cognition and seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Memantine-donepezil?
MediHelp rates the interaction as moderate. Maprotiline and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline has anticholinergic properties that oppose donepezil and can worsen cognition. Both drugs can also prolong the QT interval, and maprotiline lowers the seizure threshold.
How serious is the interaction between Maprotiline and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antidepressant with minimal anticholinergic effects. If maprotiline is used, monitor ECG, cognition and seizure risk.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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