Drug interactions
Maprotiline + Metaxalone
Severity: Moderate
Maprotiline and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant and may intensify metaxalone's drowsiness. Anticholinergic effects and a lowered seizure threshold with maprotiline add to the importance of watching for oversedation.
What this interaction means in plain words
Maprotiline and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression; possible weak additive serotonergic effects.
What to do
Monitor for excessive sedation and confusion, and for signs of serotonin toxicity. Reduce doses if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metaxalone?
MediHelp rates the interaction as moderate. Maprotiline and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant and may intensify metaxalone's drowsiness. Anticholinergic effects and a lowered seizure threshold with maprotiline add to the importance of watching for oversedation.
How serious is the interaction between Maprotiline and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and confusion, and for signs of serotonin toxicity. Reduce doses if impairment develops.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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