Drug interactions
Maprotiline + Methocarbamol
Severity: Moderate
Maprotiline and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining them can deepen drowsiness and impair alertness and psychomotor performance. Maprotiline's antihistaminic and anticholinergic effects may add to the sedation.
What this interaction means in plain words
Maprotiline and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Warn the patient about drowsiness and advise against driving or operating machinery until the response is known. Reduce the methocarbamol dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Methocarbamol?
MediHelp rates the interaction as moderate. Maprotiline and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining them can deepen drowsiness and impair alertness and psychomotor performance. Maprotiline's antihistaminic and anticholinergic effects may add to the sedation.
How serious is the interaction between Maprotiline and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and advise against driving or operating machinery until the response is known. Reduce the methocarbamol dose if excessive sedation occurs.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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