Drug interactions
Maprotiline + Methohexital
Severity: Moderate
Maprotiline and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so together they may cause excessive sedation, hypotension and respiratory depression. Maprotiline may also lower the seizure threshold.
What this interaction means in plain words
Maprotiline and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Reduce the methohexital dose as needed and monitor airway, ventilation and blood pressure. Ensure the setting has resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Maprotiline with Methohexital?
MediHelp rates the interaction as moderate. Maprotiline and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so together they may cause excessive sedation, hypotension and respiratory depression. Maprotiline may also lower the seizure threshold.
How serious is the interaction between Maprotiline and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the methohexital dose as needed and monitor airway, ventilation and blood pressure. Ensure the setting has resuscitation capability.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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