Drug interactions
Maprotiline + Mifepristone
Severity: Major
Maprotiline and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval, and maprotiline can do the same. Combined use may increase the risk of serious ventricular arrhythmia. Mifepristone also inhibits CYP2D6, which may raise maprotiline concentrations.
What this interaction means in plain words
Maprotiline and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation, plus CYP2D6 inhibition by mifepristone that may increase maprotiline exposure.
What to do
Use an alternative antidepressant if possible. If the combination is needed, obtain a baseline ECG, correct electrolytes, monitor the QTc, and consider reducing the maprotiline dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Maprotiline with Mifepristone?
MediHelp rates the interaction as major. Maprotiline and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval, and maprotiline can do the same. Combined use may increase the risk of serious ventricular arrhythmia. Mifepristone also inhibits CYP2D6, which may raise maprotiline concentrations.
How serious is the interaction between Maprotiline and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antidepressant if possible. If the combination is needed, obtain a baseline ECG, correct electrolytes, monitor the QTc, and consider reducing the maprotiline dose.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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