Drug interactions
Maprotiline + Oliceridine
Severity: Moderate
Maprotiline and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic potential combined with antidepressants raise concern for serotonin syndrome, and both drug types add CNS depression. Oliceridine has little direct serotonergic activity, so the main concern is additive sedation and respiratory depression.
What this interaction means in plain words
Maprotiline and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with a theoretical serotonergic contribution.
What to do
Use the lowest effective oliceridine dose and monitor for sedation, respiratory depression and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Maprotiline with Oliceridine?
MediHelp rates the interaction as moderate. Maprotiline and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic potential combined with antidepressants raise concern for serotonin syndrome, and both drug types add CNS depression. Oliceridine has little direct serotonergic activity, so the main concern is additive sedation and respiratory depression.
How serious is the interaction between Maprotiline and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and monitor for sedation, respiratory depression and signs of serotonin toxicity.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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