Drug interactions
Maprotiline + Orphenadrin
Severity: Moderate
Maprotiline and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant with anticholinergic and sedative effects. With orphenadrine it can cause pronounced drowsiness, confusion, constipation, urinary retention and tachycardia, and maprotiline also carries a seizure risk.
What this interaction means in plain words
Maprotiline and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Avoid in elderly patients or those with glaucoma or urinary obstruction. Otherwise use low doses and monitor for anticholinergic toxicity and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Orphenadrin?
MediHelp rates the interaction as moderate. Maprotiline and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant with anticholinergic and sedative effects. With orphenadrine it can cause pronounced drowsiness, confusion, constipation, urinary retention and tachycardia, and maprotiline also carries a seizure risk.
How serious is the interaction between Maprotiline and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in elderly patients or those with glaucoma or urinary obstruction. Otherwise use low doses and monitor for anticholinergic toxicity and sedation.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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