Drug interactions
Maprotiline + Pancuronium
Severity: Moderate
Maprotiline and Pancuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant that blocks noradrenaline reuptake and can provoke arrhythmias, while pancuronium raises heart rate through vagal blockade. Together they may increase the risk of tachyarrhythmias during anesthesia.
What this interaction means in plain words
Maprotiline and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic cardiac effects from pancuronium vagolysis and maprotiline catecholamine reuptake inhibition.
What to do
Monitor ECG and blood pressure perioperatively. Choose a more cardiostable neuromuscular blocker if arrhythmia risk is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Pancuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pancuronium
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Pancuronium?
MediHelp rates the interaction as moderate. Maprotiline and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant that blocks noradrenaline reuptake and can provoke arrhythmias, while pancuronium raises heart rate through vagal blockade. Together they may increase the risk of tachyarrhythmias during anesthesia.
How serious is the interaction between Maprotiline and Pancuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure perioperatively. Choose a more cardiostable neuromuscular blocker if arrhythmia risk is a concern.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
