Drug interactions
Maprotiline + Pilocarpine
Severity: Moderate
Maprotiline and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has anticholinergic activity that can counteract the muscarinic agonist effect of pilocarpine. This may reduce its benefit, for example in dry mouth. The effect is generally modest.
What this interaction means in plain words
Maprotiline and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism between muscarinic blockade by maprotiline and muscarinic agonism by pilocarpine.
What to do
Monitor for reduced response to pilocarpine, such as persistent dry mouth, and adjust the pilocarpine dose if needed. Consider a less anticholinergic antidepressant if the effect is relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Maprotiline with Pilocarpine?
MediHelp rates the interaction as moderate. Maprotiline and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline has anticholinergic activity that can counteract the muscarinic agonist effect of pilocarpine. This may reduce its benefit, for example in dry mouth. The effect is generally modest.
How serious is the interaction between Maprotiline and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to pilocarpine, such as persistent dry mouth, and adjust the pilocarpine dose if needed. Consider a less anticholinergic antidepressant if the effect is relevant.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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