Drug interactions
Maprotiline + Procarbazine
Severity: Contraindicated
Maprotiline and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, so combining it with maprotiline may lead to hypertensive reactions or serotonin-like toxicity.
What this interaction means in plain words
Maprotiline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Maprotiline belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition plus noradrenergic reuptake blockade increases monoaminergic activity.
What to do
Avoid the combination; allow about 14 days after stopping procarbazine before starting maprotiline. Use another antidepressant if needed during procarbazine therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Maprotiline with Procarbazine?
MediHelp rates the interaction as contraindicated. Maprotiline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, so combining it with maprotiline may lead to hypertensive reactions or serotonin-like toxicity.
How serious is the interaction between Maprotiline and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; allow about 14 days after stopping procarbazine before starting maprotiline. Use another antidepressant if needed during procarbazine therapy.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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