Drug interactions
Maprotiline + Repaglinide
Severity: Minor
Maprotiline and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline may modestly alter glucose control and could add to the glucose-lowering effect of insulin secretagogues. Repaglinide can cause hypoglycemia, so a small additive effect is possible though rarely significant.
What this interaction means in plain words
Maprotiline and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not firmly established.
What to do
Monitor blood glucose when maprotiline is started or stopped and counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Maprotiline with Repaglinide?
MediHelp rates the interaction as minor. Maprotiline and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline may modestly alter glucose control and could add to the glucose-lowering effect of insulin secretagogues. Repaglinide can cause hypoglycemia, so a small additive effect is possible though rarely significant.
How serious is the interaction between Maprotiline and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when maprotiline is started or stopped and counsel the patient on hypoglycemia symptoms.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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