Drug interactions
Maprotiline + Sertraline
Severity: Moderate
Maprotiline and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may modestly raise maprotiline levels via CYP2D6 inhibition, and both agents increase serotonergic and noradrenergic activity. This raises the risk of serotonin syndrome, seizures and QT effects.
What this interaction means in plain words
Maprotiline and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with weak-to-moderate CYP2D6 inhibition by sertraline reducing maprotiline clearance.
What to do
Use the lowest effective doses and monitor for serotonin syndrome symptoms and seizures. Consider monitoring the ECG, especially at higher sertraline doses or in patients with cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Maprotiline with Sertraline?
MediHelp rates the interaction as moderate. Maprotiline and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline may modestly raise maprotiline levels via CYP2D6 inhibition, and both agents increase serotonergic and noradrenergic activity. This raises the risk of serotonin syndrome, seizures and QT effects.
How serious is the interaction between Maprotiline and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for serotonin syndrome symptoms and seizures. Consider monitoring the ECG, especially at higher sertraline doses or in patients with cardiac risk.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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