Drug interactions
Maprotiline + Tiotropium
Severity: Moderate
Maprotiline and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant with notable anticholinergic activity. With tiotropium, antimuscarinic effects may add up, causing dry mouth, constipation, urinary retention, tachycardia and blurred vision.
What this interaction means in plain words
Maprotiline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms, especially urinary retention and ocular effects. Consider a less anticholinergic antidepressant if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Tiotropium?
MediHelp rates the interaction as moderate. Maprotiline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant with notable anticholinergic activity. With tiotropium, antimuscarinic effects may add up, causing dry mouth, constipation, urinary retention, tachycardia and blurred vision.
How serious is the interaction between Maprotiline and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially urinary retention and ocular effects. Consider a less anticholinergic antidepressant if symptoms develop.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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