Drug interactions
Maprotiline + Umeclidinium-vilanterol
Severity: Major
Maprotiline and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, can prolong the QT interval and has noradrenergic effects. Combined with vilanterol, cardiovascular effects may be potentiated, raising the risk of tachycardia and arrhythmia.
What this interaction means in plain words
Maprotiline and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and potentiation of adrenergic cardiovascular effects.
What to do
Avoid if possible, or use only with ECG and heart rate monitoring, especially in patients with cardiac disease. Correct potassium and magnesium before use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Maprotiline and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline, a tetracyclic antidepressant, can prolong the QT interval and has noradrenergic effects. Combined with vilanterol, cardiovascular effects may be potentiated, raising the risk of tachycardia and arrhythmia.
How serious is the interaction between Maprotiline and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use only with ECG and heart rate monitoring, especially in patients with cardiac disease. Correct potassium and magnesium before use.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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