Drug interactions
Maprotiline + Ziprasidone
Severity: Contraindicated
Maprotiline and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has a well-recognized QT-prolonging effect and its labeling advises against use with other QT-prolonging drugs. Adding maprotiline increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Maprotiline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Maprotiline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
What to do
Avoid the combination and use an antidepressant or antipsychotic with lower QT liability. If one drug must be switched, perform ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Maprotiline with Ziprasidone?
MediHelp rates the interaction as contraindicated. Maprotiline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone has a well-recognized QT-prolonging effect and its labeling advises against use with other QT-prolonging drugs. Adding maprotiline increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Maprotiline and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antidepressant or antipsychotic with lower QT liability. If one drug must be switched, perform ECG monitoring and correct electrolytes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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