Drug interactions
Marijuana + Methamphetamine
Severity: Moderate
Marijuana and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis combined with methamphetamine increases heart rate and may add to cardiovascular strain. Cannabis can also add to anxiety, impaired cognition or psychosis risk when used with a stimulant.
What this interaction means in plain words
Marijuana and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiovascular and psychoactive effects; any CYP2D6 effect is minor and not well established.
What to do
Counsel patients about additive tachycardia and psychiatric effects, and monitor heart rate, blood pressure and mental state, particularly in those with heart disease or psychosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Marijuana with Methamphetamine?
MediHelp rates the interaction as moderate. Marijuana and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis combined with methamphetamine increases heart rate and may add to cardiovascular strain. Cannabis can also add to anxiety, impaired cognition or psychosis risk when used with a stimulant.
How serious is the interaction between Marijuana and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive tachycardia and psychiatric effects, and monitor heart rate, blood pressure and mental state, particularly in those with heart disease or psychosis.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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