Drug interactions
Marijuana + Oxycodone
Severity: Moderate
Marijuana and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis has sedative and psychomotor-impairing effects that add to those of opioids, increasing drowsiness, dizziness and impaired judgment. Respiratory depression risk may rise at higher doses, and any pharmacokinetic effect on oxycodone is small and uncertain.
What this interaction means in plain words
Marijuana and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; a minor pharmacokinetic effect through CYP enzymes is possible but not well established.
What to do
Advise patients to avoid driving or hazardous tasks and monitor for excess sedation. Review the need for concurrent cannabis use in patients on opioids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Marijuana with Oxycodone?
MediHelp rates the interaction as moderate. Marijuana and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis has sedative and psychomotor-impairing effects that add to those of opioids, increasing drowsiness, dizziness and impaired judgment. Respiratory depression risk may rise at higher doses, and any pharmacokinetic effect on oxycodone is small and uncertain.
How serious is the interaction between Marijuana and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks and monitor for excess sedation. Review the need for concurrent cannabis use in patients on opioids.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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