Drug interactions
Marijuana + Ranolazine
Severity: Minor
Marijuana and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, so ranolazine levels might rise. The clinical significance is uncertain and not well documented.
What this interaction means in plain words
Marijuana and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids; not clearly established in humans.
What to do
Monitor for ranolazine adverse effects such as dizziness, constipation and palpitations. Counsel patients on cannabis use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Marijuana with Ranolazine?
MediHelp rates the interaction as minor. Marijuana and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, so ranolazine levels might rise. The clinical significance is uncertain and not well documented.
How serious is the interaction between Marijuana and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ranolazine adverse effects such as dizziness, constipation and palpitations. Counsel patients on cannabis use.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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