Drug interactions
Marijuana + Tramadol
Severity: Moderate
Marijuana and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes sedation and impaired psychomotor function, which add to tramadol's CNS depression. Risk of drowsiness, impaired driving and respiratory depression is increased.
What this interaction means in plain words
Marijuana and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients to avoid driving and hazardous tasks, and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Marijuana with Tramadol?
MediHelp rates the interaction as moderate. Marijuana and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes sedation and impaired psychomotor function, which add to tramadol's CNS depression. Risk of drowsiness, impaired driving and respiratory depression is increased.
How serious is the interaction between Marijuana and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous tasks, and monitor for oversedation.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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