Drug interactions
Marijuana + Trazodone
Severity: Moderate
Marijuana and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis and trazodone both cause sedation, and cannabis may impair coordination and judgment further. Cannabidiol-containing products may inhibit CYP3A4 and raise trazodone levels, but this is variable.
What this interaction means in plain words
Marijuana and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible CYP3A4 inhibition by cannabinoids.
What to do
Counsel patients about additive drowsiness and avoiding driving. Reduce the trazodone dose if excessive sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Marijuana with Trazodone?
MediHelp rates the interaction as moderate. Marijuana and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis and trazodone both cause sedation, and cannabis may impair coordination and judgment further. Cannabidiol-containing products may inhibit CYP3A4 and raise trazodone levels, but this is variable.
How serious is the interaction between Marijuana and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoiding driving. Reduce the trazodone dose if excessive sedation or hypotension occurs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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