Drug interactions
Marijuana + Trimipramine
Severity: Moderate
Marijuana and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes sedation and impairs cognition and psychomotor skills, which adds to the sedative effect of trimipramine. Cannabis can also cause tachycardia, and combined use with tricyclics has been associated with additional tachycardia and cardiovascular stress.
What this interaction means in plain words
Marijuana and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive tachycardic effects.
What to do
Advise patients to avoid cannabis or limit use, and to avoid driving. Monitor for excess sedation, tachycardia and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Marijuana with Trimipramine?
MediHelp rates the interaction as moderate. Marijuana and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes sedation and impairs cognition and psychomotor skills, which adds to the sedative effect of trimipramine. Cannabis can also cause tachycardia, and combined use with tricyclics has been associated with additional tachycardia and cardiovascular stress.
How serious is the interaction between Marijuana and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid cannabis or limit use, and to avoid driving. Monitor for excess sedation, tachycardia and confusion.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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