Drug interactions
Mavacamten + Metoprolol
Severity: Moderate
Mavacamten and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and beta-blockers have negative inotropic effects. Together they can cause excessive reduction in systolic function and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy. Metoprolol is also a CYP2D6 substrate, but mavacamten effects on it are not clinically significant.
What this interaction means in plain words
Mavacamten and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects.
What to do
Monitor LVEF and symptoms with echocardiography per mavacamten labeling. Interrupt mavacamten if LVEF falls or heart failure develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Metoprolol?
MediHelp rates the interaction as moderate. Mavacamten and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility and beta-blockers have negative inotropic effects. Together they can cause excessive reduction in systolic function and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy. Metoprolol is also a CYP2D6 substrate, but mavacamten effects on it are not clinically significant.
How serious is the interaction between Mavacamten and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and symptoms with echocardiography per mavacamten labeling. Interrupt mavacamten if LVEF falls or heart failure develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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