Drug interactions
Measles mumps and rubella vaccine live + Vedolizumab
Severity: Moderate
Measles mumps and rubella vaccine live and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMR is a live attenuated vaccine. Vedolizumab labeling advises avoiding live vaccines unless benefit outweighs risk, because of potential for reduced response or vaccine-virus infection. Systemic immunosuppression is limited, so the practical risk is likely small.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduction in immune control of live attenuated viruses by vedolizumab, which has gut-selective effects.
What to do
Complete MMR immunization before starting vedolizumab where possible. If already on therapy, give it only if benefit outweighs risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Vedolizumab?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MMR is a live attenuated vaccine. Vedolizumab labeling advises avoiding live vaccines unless benefit outweighs risk, because of potential for reduced response or vaccine-virus infection. Systemic immunosuppression is limited, so the practical risk is likely small.
How serious is the interaction between Measles mumps and rubella vaccine live and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete MMR immunization before starting vedolizumab where possible. If already on therapy, give it only if benefit outweighs risk.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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