Drug interactions
Measles vaccine + Vedolizumab
Severity: Moderate
Measles vaccine and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine is a live attenuated vaccine. Vedolizumab labeling recommends avoiding live vaccines unless benefit outweighs risk, because of potential for reduced vaccine response or vaccine-virus infection. Systemic immunosuppression from vedolizumab is limited, so the practical risk is likely small.
What this interaction means in plain words
Measles vaccine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduction in immune control of live attenuated virus by vedolizumab, which has gut-selective lymphocyte trafficking effects.
What to do
Where possible, give required live vaccines before starting vedolizumab. If already treated, give them only when benefit clearly outweighs risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Measles vaccine with Vedolizumab?
MediHelp rates the interaction as moderate. Measles vaccine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Measles vaccine is a live attenuated vaccine. Vedolizumab labeling recommends avoiding live vaccines unless benefit outweighs risk, because of potential for reduced vaccine response or vaccine-virus infection. Systemic immunosuppression from vedolizumab is limited, so the practical risk is likely small.
How serious is the interaction between Measles vaccine and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give required live vaccines before starting vedolizumab. If already treated, give them only when benefit clearly outweighs risk.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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