Drug interactions
Mechlorethamine + Oxaliplatin
Severity: Moderate
Mechlorethamine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are DNA-damaging cytotoxics that suppress bone marrow. Used together they can produce additive neutropenia, thrombocytopenia and anemia, raising the risk of infection and bleeding.
What this interaction means in plain words
Mechlorethamine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression from two DNA-alkylating or cross-linking agents.
What to do
Monitor complete blood counts regularly and delay or reduce doses for neutropenia or thrombocytopenia. Watch for signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Oxaliplatin?
MediHelp rates the interaction as moderate. Mechlorethamine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are DNA-damaging cytotoxics that suppress bone marrow. Used together they can produce additive neutropenia, thrombocytopenia and anemia, raising the risk of infection and bleeding.
How serious is the interaction between Mechlorethamine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and delay or reduce doses for neutropenia or thrombocytopenia. Watch for signs of infection.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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