Drug interactions
Mechlorethamine + Sarilumab
Severity: Moderate
Mechlorethamine and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a cytotoxic alkylating agent that can be myelosuppressive, particularly with systemic use. Combined with sarilumab, which itself raises the risk of serious infection and neutropenia, infection risk may increase.
What this interaction means in plain words
Mechlorethamine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Sarilumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor neutrophil counts and for signs of infection, and interrupt sarilumab if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarilumab
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Sarilumab?
MediHelp rates the interaction as moderate. Mechlorethamine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a cytotoxic alkylating agent that can be myelosuppressive, particularly with systemic use. Combined with sarilumab, which itself raises the risk of serious infection and neutropenia, infection risk may increase.
How serious is the interaction between Mechlorethamine and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and for signs of infection, and interrupt sarilumab if a serious infection develops.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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