Drug interactions
Mechlorethamine + Sirolimus
Severity: Moderate
Mechlorethamine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow and immune function, so combining them can deepen neutropenia and other cytopenias and raise the risk of serious infection. The effect is additive rather than pharmacokinetic.
What this interaction means in plain words
Mechlorethamine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic myelosuppression and immunosuppression.
What to do
Monitor complete blood counts regularly and watch for signs of infection. Reduce the dose or delay treatment if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Sirolimus?
MediHelp rates the interaction as moderate. Mechlorethamine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow and immune function, so combining them can deepen neutropenia and other cytopenias and raise the risk of serious infection. The effect is additive rather than pharmacokinetic.
How serious is the interaction between Mechlorethamine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for signs of infection. Reduce the dose or delay treatment if significant cytopenias develop.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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