Drug interactions
Meclizine + Paromomycin
Severity: Minor
Meclizine and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine may hide vestibular symptoms that signal aminoglycoside ototoxicity. Oral paromomycin is minimally absorbed, so the practical risk is low except in severe bowel disease or renal impairment.
What this interaction means in plain words
Meclizine and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meclizine belongs to Respiratory; Paromomycin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic masking of vestibular symptoms; no pharmacokinetic interaction.
What to do
Consider audiometry or renal monitoring in patients with impaired renal function or inflamed gut mucosa taking paromomycin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclizine
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Meclizine with Paromomycin?
MediHelp rates the interaction as minor. Meclizine and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclizine may hide vestibular symptoms that signal aminoglycoside ototoxicity. Oral paromomycin is minimally absorbed, so the practical risk is low except in severe bowel disease or renal impairment.
How serious is the interaction between Meclizine and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider audiometry or renal monitoring in patients with impaired renal function or inflamed gut mucosa taking paromomycin.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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