Drug interactions
Meclizine + Risperidone
Severity: Moderate
Meclizine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic activity that may add to the sedation and anticholinergic effects of risperidone. Meclizine is also a CYP2D6 inhibitor in vitro, which could modestly raise risperidone exposure.
What this interaction means in plain words
Meclizine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects, with possible weak CYP2D6 inhibition by meclizine.
What to do
Monitor for excess sedation, confusion, constipation and urinary retention, especially in older patients. Reduce one agent if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Risperidone?
MediHelp rates the interaction as moderate. Meclizine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine with anticholinergic activity that may add to the sedation and anticholinergic effects of risperidone. Meclizine is also a CYP2D6 inhibitor in vitro, which could modestly raise risperidone exposure.
How serious is the interaction between Meclizine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, confusion, constipation and urinary retention, especially in older patients. Reduce one agent if effects are troublesome.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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