Drug interactions
Meclizine + Trimipramine
Severity: Moderate
Meclizine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine has antimuscarinic and sedating properties that add to those of trimipramine. Patients may have drowsiness, dry mouth, blurred vision, constipation and urinary retention, and older adults may become confused.
What this interaction means in plain words
Meclizine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic and H1-antihistaminic effects.
What to do
Use the lowest effective meclizine dose and counsel about driving and alcohol. Monitor older patients for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Trimipramine?
MediHelp rates the interaction as moderate. Meclizine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine has antimuscarinic and sedating properties that add to those of trimipramine. Patients may have drowsiness, dry mouth, blurred vision, constipation and urinary retention, and older adults may become confused.
How serious is the interaction between Meclizine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meclizine dose and counsel about driving and alcohol. Monitor older patients for confusion and urinary retention.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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